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KMID : 1007520130220041091
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Food Science and Biotechnology
2013 Volume.22 No. 4 p.1091 ~ p.1096
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Kiwifruit (Actinidia chinensis) Extract Annuls Chronic Insulininduced Insulin Resistance in L6 Skeletal Muscle Cells
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Kim Jeong-Hee
Kim Jong-Whi
Kim Seong-Cheol
Lee Young-Jae
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Abstract
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Kiwi fruit has long been believed to be beneficial to human health due to its numerous biological actions; however the pharmacological mechanisms associated with these benefits are incompletely understood. In the present study, the effects of ‘Halla Gold’ (Actinidia chinensis var.), a new kiwifruit cultivar bred by the Jeju Rural Development Administration (RDA), on chronic insulin-induced insulin resistance in L6 skeletal muscle cells was investigated. Chronic insulin reduced phosphorylation of Akt and GSK- 3α/β, and increased phosphorylation of glycogen synthase (GS). Furthermore, glucose consumption and glucose transporter 4 (Glut4) translocation to the plasma membrane were inhibited. However, ‘Halla Gold’ extract (HGE) increased phosphorylation of Akt and GSK-3α/β concomitantly with decreased phosphorylation of GS. Moreover, HGE improved insulin-stimulated glucose consumption by facilitating Glut4 translocation and this stimulation was suppressed by inhibition of PI3 kinase. Together, our data suggest that ‘Halla Gold’ extract abolishes chronic insulin-induced insulin resistance through the PI3K/Akt pathway.
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KEYWORD
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‘Halla Gold’, kiwifruit, insulin resistance, PI3K/Akt, L6 skeletal muscle cell
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